Assessment of urinary pharmacokinetics and pharmacodynamics of orbifloxacin in healthy dogs with ex vivo modelling
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چکیده
منابع مشابه
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چکیده ندارد.
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P-glycoprotein (P-gp) and cytochrome P450 3A4 (CYP3A4) play a significant role in the disposition and elimination of drugs. The objective of this study was to investigate the mechanism underlying the interaction between sitagliptin (substrate of P-gp and CYP3A4) and verapamil (known modulator of P-gp and CYP3A4) using in vivo, ex vivo and in situ models. Rats were treated with sitagliptin (10 m...
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ژورنال
عنوان ژورنال: Journal of Medical Microbiology
سال: 2017
ISSN: 0022-2615,1473-5644
DOI: 10.1099/jmm.0.000476